Jeanne Jiang's Research Contributions at Hunter College

Jeanne Jiang's research contributions at Hunter College span a diverse array of fields, reflecting an interdisciplinary approach to scientific inquiry. These contributions include not only research conducted directly at Hunter College but also collaborations and publications with researchers at other institutions, including IBM's Thomas J. Watson Research Center. This article aims to illuminate the breadth and depth of Jiang's work, highlighting specific projects and collaborations.

Focus on Chromosomal Dysfunction and Cancer Development

John Maciejowski's lab focuses on a dysfunction of the chromosomes that affects cancer development. Maciejowski's experiences and training at GSK helped him get a fast start at Rockefeller University, where he did his postdoctoral work.

Research in Plant Pathology: Fire Blight Disease

One significant area of research involves the study of fire blight, a devastating plant disease affecting apple and pear trees, as well as other members of the family Rosaceae. The disease is caused by the bacterium Erwinia amylovora, which is related to common human pathogens including E. coli, various Salmonella species, and Yersinia pestis, the cause of plague.

The Virulence Mechanisms of Erwinia amylovora

Fire blight bacteria infect and destroy blossoms, immature fruit, and foliage, leaving a blackened, scorched appearance. Epidemics can wipe out entire orchards. In some regions, fire blight disease is such a severe problem that apple and pear trees are difficult to grow commercially. During the establishment of an infection, the fire blight pathogen unleashes an arsenal of chemical weapons, virulence factors, aimed at defeating plant defenses. Several of these virulence factors are toxic proteins that are directly injected into the plant cells at the site of infection via a type III secretion system. Others may possibly take the form of chemical toxins that are synthesized and secreted in order to cause injury to the plant.

Genome sequencing studies at Cornell University have identified a ~62 kilobase region within the bacterial chromosome where a number of genes required for pathogenicity are located. Many of the genes in this region exhibit sequence similarity to known or suspected virulence factors in other pathogens. One locus of particular interest and significance contains a series of five genes, hsvA, hsvB, hsvC, orf12, and orf13, organized into two operons, which are predicted to encode proteins having enzymatic function.

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Investigating Biochemical Activities and Virulence Factors

To investigate the biochemical activity of these proteins and gain insight into their roles in pathogenicity, researchers are working to clone these five genes into a suitable heterologous prokaryotic expression system to produce recombinant protein, developing appropriate purification strategies, and characterizing the biochemical functions of these five proteins. The enzymatic activity and substrate specificity are investigated using various in vitro substrate binding and enzymatic activity assays that have been applied successfully in other systems. The results of these studies are expected to provide important insights into the enzymatic capabilities of these five proteins and will lead to testable hypotheses about the in vivo substrates that may be used and the potential products that may arise during infection, ultimately shedding light upon the role of these proteins as virulence factors in E. amylovora and suggesting novel strategies for combating fire blight disease.

Student Research on Fire Blight Pathogen

Student research symposia have featured work related to the fire blight pathogen, Erwinia amylovora. These include:

Cloning, Expression, and Biochemical Characterization of HsvB, a Virulence Factor from the Fire Blight Pathogen.
Expression, purification, and biochemical characterization of HsvA, a protein required for full virulence in the plant pathogen, Erwinia amylovora.
Cloning and expression of OrfC and DspF, molecular chaperones in Erwinia amylovora.
Heterologous Expression and Functional Characterization of Secretion and Nuclear Localization Signals in OrfM, a Potential Virulence-Associated Protein from the Plant Pathogen Erwinia amylovora.
Cloning and expression of virulence-associated protein Orf13 from Erwinia amylovora.
Heterologous expression of OrfA from Erwinia amylovora for protein characterization.
Cloning and expression of Orf12, a virulence-associated protein from Erwinia amylovora.

Bio-Inspired Molecules and Molecular Assemblies

Jiang's research interests also encompass the engineering of bio-inspired molecules and molecular assemblies using organic chemistry. Biological phenomena, concepts, and structures have recently provided material scientists with great inspiration for the development of novel materials having attractive structures and properties. Organic chemistry has played a critical role in the development of bio-inspired materials, and the resulting materials have been widely used in various practical applications such as biological sensing and biomedical diagnostics. Strategies are developed to prepare novel bio-inspired organic materials and seek their applications in bionanotechnology.

Detection of Biomolecules and Biosensors

Detection of biomolecules is a critical step in various practical biotechnologies, including biomedical diagnostics and biological sensing. To develop surface-based biosensors, the biochemical event occurring at an interface should be converted into a measurable output signal to be detected. Past studies showed that liquid crystals can be effectively used as a signal transducer to amplify and report chemical and biochemical events on a surface. A novel strategy is developed to incorporate peptide substrates into an aqueous-liquid crystal interface.

Dendrimer-Nanoparticle Nanocomposites for MRI

Dendrimers are highly branched, highly functionalized polymers with a well-defined symmetrical structure. Poly(amidoamine) (PAMAM) dendrimers consisting of beta-alanine subunits are often called "artificial proteins" due to their similarities in sizes, shapes, and structures. A novel method is developed to prepare a covalently conjugated dendrimer-nanoparticle nanocomposite which can be used for targeted diagnostic magnetic resonance imaging (MRI).

Protease Assay System Using Gold Nanoparticles

Nanometer-scale metal particles have been enjoying a great deal of interest from researchers due to their potential applications in electronics, catalysis, molecular recognition, and chemical and biological sensing. The size-dependent electronic, magnetic, and optical properties of metal nanoparticles (quantum size effect) have been utilized in the field of biomolecular diagnostics and detections. A simple assay system is developed for proteases using gold nanoparticles immobilized at peptide-modified interfaces. To prepare the system, peptide substrates that can be hydrolyzed by a protease will be immobilized to polymer or metal surface. Subsequently, gold nanoparticles will be conjugated to the immobilized peptide substrates.

Publications on Bio-Inspired Materials

Publications in this area include:

"Analysis of the Wettability of Partially Fluorinated Polymers Reveals the Surprisingly Strong Polar or Acid-Base? Character of Poly(vinylidene Fluoride)"
"A Sensing Device Using Liquid Crystal in a Micropillar Array Supporting Structure"
"Ordering Transitions in Thermotropic Liquid Crystals Induced by the Interfacial Assembly and Enzymatic Processing of Oligopeptide-Amphiphiles"
"Preparation, Characterization, and Chemical Stability of Gold Nanoparticles Coated with Mono-, Bis-, and Tris-Chelating Alkanethiols"
"The Wettability of Fluoropolymer Surfaces: Influence of Surface Dipoles"
"Coupling of the Plasmon Resonance of Chemically Functionalized Gold Nanoparticles to Local Order in Thermotropic Liquid Crystals"
"Formation of Oligopeptide-Based Polymeric Membranes at Interfaces Between Aqueous Phases and Thermotropic Liquid Crystals"
"Influence of 4-Cyano-4â-biphenylcarboxylic Acid on the Orientational Behavior of Cyanobiphenyl Liquid Crystal"
"Synthesis of Tetraoctylammonium-Protected Gold Nanoparticles with Improved Stability"
"Systematic Control of the Packing Density of Alkyl Chains in Self-Assembled Monolayers on Gold Generated from Chelating Alkanethiols"
"Synthesis and Ring-Opening Metathesis Polymerization (ROMP) of Aryl-Substituted 1,1â-(1,3-Butadienylene)ferrocenes"
"ROMP of t-Butyl-Substituted Ferrocenophanes Affords Soluble Conjugated Polymers that Contain Ferrocene Moieties in the Backbone"
"Loosely Packed Self-Assembled Monolayers on Gold Generated from 2-Alkyl-2-methylpropane-1,3-dithiols"
"Stability of Aliphatic Dithiocarboxylic Acid Self-Assembled Monolayers on Gold"
"Carbon-Bridged Ferrocenophanes"
"Synthesis, Characterization, and Reactivity of ReOMe2(bipy)X Complexes"
"Device and Methods for Liquid Crystal-Based Bioagent Detection"
"Cholesterol Biosynthesis Inhibitors"
"13, 13Î±-Didehydroberberine Derivatives"
"Aryl Benzoyl Urea Derivative and Pesticidal Composition Comprising the Same"
"Pharmaceutical Composition Comprising 5,6-Dihydrodibenzo[a,g]quinolizinium Derivatives and the Salts Thereof"
"Antifungal Formulation Comprising Protoberberine Derivatives and Salts Thereof"
"Dibenzo-[a.g]quinolizinium Derivatives and the Salts Thereof"
"2-Chloro-3,5-bis(trifluoromethyl)phenyl Benzoyl Urea Derivative and Process for Preparing the Same"
"Pharmaceutically Available Protoberberine Salts Derivatives, and Protoberberine Derivatives and Salts Thereof"

Computational Chemistry and Liquid Crystals

Computational chemistry is being used to determine conjugation, orientation, and rotational barriers of substituted cyclopropyl benzene compounds of interest for various applications, including the development of new liquid crystals. Information gleaned from studying moieties at each end of the proposed structures can be used to guide synthesis of compounds with desirable liquid crystal behavior. A conformation energy analysis is ongoing for various structures, including norbornadiene-quadricyclane systems of interest as molecular switches for information or solar energy storage.

Theoretical Level and Software

All structure characterizations are at the DFT/B3LYP/6-311++G(d,p) theoretical level with thermal and zpve corrections. Density Functional Theory has been found to be a reliable and relatively fast method for large, ringed systems. Calculations are routinely performed using the Gaussian 03 suite of programs.

Ab Initio Molecular Orbital Study

An Ab Initio Molecular Orbital Study of the Reduction of Carbonyls by Alkylaluminum Complexes was conducted.

Linguistics and Talking Dictionaries

Jiang's research also extends to the field of linguistics, specifically in the creation of talking dictionaries for various indigenous languages.

Talking Dictionaries Projects

Talking dictionaries have been developed for the following languages:

Achi
Akateko
Awakateko
Chikunda
Ch'orti'
Chuj
Embera
Foe
Futuna Aniwa
Ho

Other Research and Publications

Jiang's research portfolio includes a wide array of publications and presentations across various disciplines.

Education and STEM

Conducting Impactful Research at Primarily Undergraduate Institutions
Equity and Inclusion Considerations in CS Education for Students Living With Mental Health And Medical Conditions
Experiences of Undergraduate Computer Science Students Living With Mental Health Conditions
Exploring Equity, Diversity, And Inclusion In Computer Science Undergraduate Curricula
Improving Retention and Success of Science, Technology, Engineering, and Math (STEM) Majors in Higher Education

Environmental Science and Earth Systems

'Earth System Engineersâ And The Cumulative Impact Of Organisms In Deep Time
Gratitude Letters To Natural Places Promote Ecospirituality Via Increased Anthropomorphism
Gratitude Letters To Nature: Effects On Self-Nature Representations And Pro-Environmental Behavioral Intentions

Social Sciences and Humanities

Misogyny in Medicineâs Margins: Patientsâ and Physiciansâ Conflicts, Challenges, and Camaraderie in Endometriosis Care
Qhia Peb Tus Kheej: HMong Resistance using Community-Based Educational Spaces in Vietnam
v. Texas On State Challenges To Immigration Enforcement Priorities
Enfermedades Argentinas: 16 historias
Ethical Implications Of Being A Holobiont
Exploitation on the High Seas: Transnational Capital and Workers Rights in the Global Cruise Industry
Exploring Learning Possibilities in the Museum: Contrasting Cases
Federal Aid To Women And Children: The Childrenâs Bureau, The Social Security Act, And Political Development Victories And Failures
Feminisms, Psychologies, And The Study Of Social Life
Field Notes on Repair: 5: Infrastructuring
âFinally girls hitting a celly:â Emotions and Gender Embodiment in Competitive Swimmersâ Post-Race Celebrations
Finding Agency: Supporting Teachers and Students through TrUDL
Flushed with Challenges: A Case Study into Sanitation Service Delivery in a Cape Town Informal Settlement
Foe Talking Dictionary
For Educators Grappling With Student Protests, Hereâs How To Play A Supporting Role
Forever Competition: The End-Game Of SinoâUS Rivalry
Freedom And Its Discontents: A Relational Reconstruction
From City To Metropolis: Planning Without Politics In Hong Kong
From Personal to Institutional: The Struggle of Maintaining Community Archives
Full Issue: Volume 4, Issue 1
Full Issue: Volume 6, Issue 1
Full Issue: Volume 6, Issue 2
Gender Categorization And Memory In Transgender And Cisgender People
Gendered Dimensions Of Psychological Suffering And Mental Distress In Sri Lanka
GenealogÃa De La Identidad HÃbrida En Narrativas Curativas: Las Que Se Atrevieron (2017) E Hija Del Camino (2019), De LucÃa AsuÃ© MbomÃo Rubio
GO BIRDS: Sports Fandom and Civic Identity
Gone with the Wind: The Confederacy's Trojan Horse
Habsburg Encounters With Native America: Familiar Strangers
Harvests Of Liberation: Cotton, Capitalism, And The End Of Empire In Egypt
Hay Comida en la Casa: Study on Food Inaccessibility in NYC
Heroes And Villains?
Higher Turnout, Greater Inequality? Presidential Voting, 2016 To 2020
Historians Disagree: Atlantic World History
How Insider-Led Processes Lead To Localization: The Case Of Digital Technology And Humanitarian Protection
How Much Does The IMF Care About Inequality? Dynamics Of Fragmented Institutional Change And Mission-Consistent Adaptation
How Parties And Ambitious Politicians Undermined American DemocracyâAnd The Reforms That Might Save It
I Am Prone To Growing Old
âI Donât Do Horror, Ryan Cooglerâ â Black Magicâs Dr. Yvonne Chireau On Sinners And Bringing Hoodoo To Life
Imagination, Sensation, And Habits: Medical Rhetoric And Popular Literature In Perceptions Of The Paris Opera: Response To âDr. Louis VÃ©ron, Medical Philosophy, And Medical Practice At The Paris Operaâ By Elizabeth Claire
In Pursuit Of The Harris Doctrine
In Search Of The Biden Doctrine
In Sickness and In Health: Care and Complacency in Aid Efforts for Migrant Youth in Eastern France
Indigenismo, Anti-Communism, and la RevoluciÃ³n: Historicizing The Relationship Between State-Sponsored Indigenism and Anti-Communism in Post-Revolutionary Mexico
Indigenous Influences On The Art Of Will Barnet
In The Kingdom Of The Thunder Dragon: Happiness, History, And Environment In A Changing Bhutan
Introduction
Introduction: Male Supremacy Symposium
Ellen McCrann Memorial Lecture: âThe Present Defenceless State of the Countryâ: Gunpowder Plots in Revolutionary South Carolina

Biological and Medical Sciences

Inflammasomes Primarily Restrict Cytosolic Salmonella Replication Within Human Macrophages
Interaction Of N-Methylmesoporphyrin IX With A Hybrid Left-/Right-Handed G-Quadruplex Motif From The Promoter Of The SLC2A1 Gene
Life-course origins of social inequalities in adult immune cell markers of inflammation in developing southern Chinese population: the Guangzhou Biobank Cohort Study
Parental Death during Childhood and Adult Cardiovascular Risk in a Developing Country: The Guangzhou Biobank Cohort Study
Childhood meat eating and inflammatory markers: The Guangzhou Biobank Cohort Study
Assessment of the 2009 Pandemic H1N1 Influenza A in Children and Their Contacts: A Systematic Review and Meta-Analysis
Awareness and Interest in Intrauterine Contraceptive Device Use among HIV-Positive Women in Cape Town, South Africa
A cross-sectional description of social capital in an international sample of persons living with HIV/AIDS (PLWH)
Cytomegalovirus antibodies in dried blood spots: a minimally invasive method for assessing stress, immune function, and aging
Drug Discovery Using Chemical Systems Biology: Weak Inhibition of Multiple Kinases May Contribute to the Anti-Cancer Effect of Nelfinavir
DNA Adducts of Decarbamoyl Mitomycin C Efficiently Kill Cells without Wild-Type p53 Resulting from Proteasome-Mediated Degradation of Checkpoint Protein 1
Early Invasion of Brain Parenchyma by African Trypanosomes
Experimentally Induced Sexual Behavior In Male Gray Treefrogs Activates The HPG But Not The HPI Axis
Functional Connectivity Of Red Chlorophylls In Cyanobacterial Photosystem I Revealed By Fluence-Dependent Transient Absorption
Genome Stability of Lyme Disease Spirochetes: Comparative Genomics of Borrelia burgdorferi Plasmids
Hunter-Gatherer Energetics and Human Obesity
Identifying The Top TESS Objects Of Interest For Atmospheric Characterization Of Transiting Exoplanets With JWST
Impact Of ASL Exposure On Spoken Phonemic Discrimination In Adult CI Users: A Functional Near-Infrared Spectroscopy Study
Individual Differences In Leveraging Regularity In Emergent L2 Readers In Rural CÃ´te dâIvoire
Methamphetamine Induces Striatal Cell Death Followed by the Generation of New Cells and a Second Round of Cell Death in Mice
Multiscale modeling of the causal functional roles of nsSNPs in a genome-wide association study: application to hypoxia
Testosterone therapy and cardiovascular events among men: a systematic review and meta-analysis of placebo-controlled randomized trials
Synergistic Inhibition of Survival, Proliferation, and Migration of U87 Cells with a Combination of LY341495 and Iressa
Moderate Alcohol Use and Cardiovascular Disease from Mendelian Randomization
Consumers' Perceptions of Patient-Accessible Electronic Medical Records
Risk Factor Detection as a Metric of STARHS Performance for HIV Incidence Surveillance Among Female Sex Workers in Kigali, Rwanda
Inhibition of Pokeweed Antiviral Protein (PAP) by turnip mosaic virus genome-linked protein (VPg)
Lesula: A New Species of Cercopithecus Monkey Endemic to the Democratic Republic of Congo and Implications for Conservation of Congoâs Central Basin
Evidence for a Grooming Claw in a North American Adapiform Primate: Implications for Anthropoid Origins
Coordination between proteasome impairment and caspase activation leading to TAU pathology: neuroprotection by cAMP
Understanding and Addressing Unique Needs of Diabetes in Asian Americans, Native Hawaiians, and Pacific Islanders
Association of Adherence Support and Outreach Services with Total Attrition, Loss to Follow-Up, and Death among ART Patients in Sub-Saharan Africa
The Role of Dairy Products and Milk in Adolescent Obesity: Evidence from Hong Kongâs ââChildren of 1997ââ Birth Cohort
Competition Between Conjugation and M13 Phage Infection in Escherichia coli in the Absence of Selection Pressure: A Kinetic Study
Trends in Mortality from Septicaemia and Pneumonia with Economic Development: An Age-Period-Cohort Analysis
How Does Socioeconomic Development Affect COPD Mortality? Population, NHANES 2003â2006
Differences between Trypanosoma brucei gambiense groups 1 and 2 in their resistance to killing by trypanolytic factor 1
Age-Related Deficits in Spatial Memory and Hippocampal Spines in Virgin, Female Fischer 344 Rats
Assessing Syndromic Surveillance of Cardiovascular Outcomes from Emergency Department Chief Complaint Data in New York City
The Association of Tree Pollen Concentration Peaks and Allergy Medication Sales in New York City: 2003â2008

Physics, Mathematics, and Computer Science

Exact Treatment Of Weak Dark Matter-Baryon Scattering For Linear-Cosmology Observables
Existence Of Maximal And Minimal Weak Solutions And Dinite Difference Approximations For Elliptic Systems With Nonlinear Boundary Conditions
Extending The Reach Of The Point-To-Set Principle
Finite Odometer Factors Of Rank One Group Actions
Functional Explanations Link Gender Essentialism And Normativity
How Cultural Input Shapes The Development Of Idealized Biological Prototypes
How Much Time To Figure Out How To Get Where? Route Planning And Subjective Stress Under Time Pressure
Implied Occlusion And Subset Underestimation Contribute To The Weak-Outnumber-Strong Numerosity Illusion
Intensional Functions
Linkage disequilibrium based genotype calling from low-coverage shotgun sequencing reads
Quantum learning without quantum memory
Reactome: a database of reactions, pathways and biological processes
The (Coming) Social Media Revolution in the Academy
Insightful Problem Solving in an Asian Elephant
Convergence of discrete measures and a certain number theoretical hypothesis
On the self linking of a knotII
The complete and precise structure of closed simply connected topological manifolds of dimensions 4,5,6,7,…

Labor and Urban Planning

The Chill of a Wintry Light? Borough of Duryea v. Guarnieri and the Right of Petition in Public Employment
Utilizing the reaction of degeneration test for individuals with focal paralysis
Interrupted Cities And Open Futures: Architectural Scenario Planning And The Case of Amaravati
Card Check Labor Certification: Lessons from New York
Public Sector Labor Law and History: The Politics of Ancient History?
Workplace Consequences of Electronic Exhibitionism and Voyeurism
Some Think of the Future: Internet, Electronic, and Telephonic Labor Representation ElectionsLabor Representation Elections

Astronomy and Astrophysics

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1112+3548_NIR_SpeX
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0107+0041_NIR_SpeX
1146+2230_NIR_SpeX
1228-1547_NIR_SpeX
1239+5515_NIR_SpeX

Collaborations and Affiliations

Jiang's research is often conducted in collaboration with researchers at other institutions. These include:

IBM Thomas J. Watson Research Center
Columbia University
NCCR Nanoscale Science, Institut fuer Physik Klingelbergstr
Natl. Inst. Adv. Indust. Sci

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